Cortical Cerebellar Abiothrophy (NCCD) – Vizsla
Kodas: H318
Short description
Cerebellar cortical degeneration (CCD) is a neurodegenerative disease process affecting many dog breeds.
General information
Cerebellar cortical degeneration (CCD) is a neurodegenerative disease process affecting many dog breeds. The disease affects a specific area of the brain known as the cerebellum. In cerebellar degeneration, the cells within the cerebellum die, causing neurological symptoms in dogs.
This variant of the disorder, also known as Neonatal Cortical Cerebellar Degeneration (NCCD), is found in the Vizsla. It is caused by a recessive mutation to the gene SNX14.
Specifications
| Breeds | |
|---|---|
| Gene | SNX14 |
| Chromosome | 12 |
| Mutation | c.2653+1G>A |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | NCCD |
Clinical features
The age of onset ranges from neonatal to early onset from weeks to months. Symptoms include walking abnormality, broad stance, swaying, muscle tremors with eating and performing activity, head tilt, loss of coordination and abnormal posture.
References
Pubmed ID: 27566131
Year published: 2016
Omia ID: 2034
Omia variant ID:
Turnaround information
- 10 working days