Dandy-Walker-Like Malformation (DWLM) / Cerebellar Hypoplasia (CH) – Eurasier
Kodas: H355
Short description
Dandy-Walker-like malformation (DWLM), a form of cerebellar hypoplasia (CH), is a disorder caused by abnormal brain development, which in turn causes a lack of muscle coordination.
General information
Dandy-Walker-like malformation (DWLM), a form of cerebellar hypoplasia (CH), is a disorder caused by abnormal brain development, which in turn causes a lack of muscle coordination. DWLM in the Eurasier is caused by a recessive mutation to the gene VLDLR.
Specifications
| Breeds | |
|---|---|
| Gene | VLDLR |
| Chromosome | 1 |
| Mutation | c.1713delC |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | DWLM |
Clinical features
Affected dogs begin to present symptoms when they start to walk. These symptoms include rolling and/or leaning, tremors, hypermetric gait (movement of the legs beyond the intended goal), loss of menace response and other difficulties potentially due to processing information of the senses.
References
Pubmed ID: 25668033
Year published: 2015
Omia ID: 1947
Omia variant ID:
Turnaround information
- 10 working days