Severe Combined Immunodeficiency (SCID, PRKDC-related) – Jack Russel Terrier
Kodas: H423
Short description
Severe combined immunodeficiency (SCID) is a immuno deficiency disorder in dogs.
General information
Severe combined immunodeficiency (SCID) is a immuno deficiency disorder in dogs. This test is specific for a variant found in Jack Russel Terriers and is caused by an autosomal recessive mutation in the PRKDC gene. Dogs with SCID can not produce a protein important for proper immune function. Dogs without a proper immune function are vulnerable to severe recurrent or chronic bacterial, viral and fungal infections.
Specifications
| Breeds | |
|---|---|
| Gene | PRKDC |
| Chromosome | 29 |
| Mutation | c.10879G>T |
| Organ | Respiratory System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
Clinical features
Symptoms are observed at around 12 to 14 weeks of age and include failure to thrive, poor growth, weight loss, lethargy, diarrhea, vomiting and lack of palpable lymph nodes.
References
Pubmed ID: 11867233
Year published: 2002
Omia ID: 220
Omia variant ID:
Turnaround information
- 10 working days