Musladin-Lueke Syndroom (MLS)
Kodas: H424
Short description
Musladin-Lueke Syndrome is a heritable disease specific to Beagles which causes tightened skin, stiff joints and a “ballerina”-like tip-toed gait.
General information
Musladin-Lueke Syndrome is a heritable disease specific to Beagles which causes tightened skin, stiff joints and a “ballerina”-like tip-toed gait. Originally called Chinese Beagle Syndrome, it was renamed after prolific Beagle breeders Anton Musladin and Ada Lueke. It is a recessive disorder, caused by a defective ADAMTSL2 gene.
Specifications
| Breeds | |
|---|---|
| Gene | ADAMTSL2 |
| Chromosome | 9 |
| Mutation | c.661C>T |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | MLS |
Clinical features
Affected dogs are short, with thick and tight skin, severely restricted joint mobility, and the tendency to walk on the very tips of their toes. They develop distinctive, unusually broad heads, with wide-set slanted eyes and creased ears. Heart disease may also be associated with the condition.
References
Pubmed ID: 20862248
Year published: 2010
Omia ID: 1509
Omia variant ID:
Turnaround information
- 10 working days