Glanzmann’s Thrombasthenia (GT) 2 – Dog
Kodas: H447
Short description
Glanzmann’s Thrombasthenia (GT) is a bleeding disorder caused by defective platelets, which can result in uncontrolled bleeding.
General information
Glanzmann’s Thrombasthenia (GT) is a bleeding disorder caused by defective platelets, which can result in uncontrolled bleeding. This variant of the disease, Type I Glanzmann’s Thrombasthenia, is caused by a recessive mutation to the gene ITGA2B. It is observed in the Great Pyrenees. A related variant is found in the Scottish Deerhound.
Specifications
| Breeds | |
|---|---|
| Gene | ITGA2B |
| Chromosome | 9 |
| Mutation | c.1360_1373dup |
| Organ | Cardiovascular System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Incomplete Dominant |
Clinical features
Affected dogs are susceptible to excessive bleeding, such as nosebleeds or bleeding from the gums during tooth eruption. Blood analysis will show normal platelet counts but minimal platelet activity.
References
Pubmed ID: 11105947
Year published: 2000
Omia ID: 1000
Omia variant ID:
Turnaround information
- 10 working days