FN, Familial Nephropathy – (English) Cocker Spaniel
Kodas: H676
Short description
Nephropathy is the collective name for kidney diseases.
General information
Nephropathy is the collective name for kidney diseases. This test analyses a variant of nephropathy, Autosomal Recessive Hereditary Nephropathy (ARHN) that occurs in the English Cocker Spaniel. The disorder is caused by a recessive mutation to the gene COL4A4. A similar variant also occurs in the English Springer Spaniel.
Specifications
| Breeds | |
|---|---|
| Gene | COL4A4 |
| Chromosome | 25 |
| Mutation | c.115A>T |
| Organ | Urinary system |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | ARHN; HN; FN |
Clinical features
ARHN causes kidney failure in affected dogs. Symptoms of kidney failure can include weight loss, increased micturition, increased thirst, lethargy, loss of appetite, vomiting, bad breath and dehydration. Blood analysis can amongst others show increased levels of creatinine and SDMA. The onset is rapid, and symptoms may be severe enough to require euthanasia on humane grounds.
Additional information
Hereditary nephropathy can also be caused by other mutations.
References
Pubmed ID: 17552442
Year published: 2007
Omia ID: 2618
Omia variant ID:
Turnaround information
- 10 working days