Curly Coat (c1) – Dog
Kodas: H921
Short description
An incomplete dominant mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs.
General information
An incomplete dominant mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs. The variant analysed in this test, designated as c^1, is originally found in the Portuguese Water Dog, though observed in many other breeds. A related variant, c^2, has been observed in the Bichon Frise, Chesapeake Bay Retriever, Curly-coated Retriever, Irish Terrier, Lagotto Romagnolo and Spanish Water Dog.
Specifications
| Breeds | All Breeds |
|---|---|
| Gene | KRT71 |
| Chromosome | 27 |
| Mutation | c.451C>T |
| Organ | Integumentary System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Incomplete Dominant |
Clinical features
Affected dogs with two mutated alleles have a curly-haired coat instead of a straight coat. Animals that carry one mutated allele have an in-between phenotype: a wavy coat. Coats must be of sufficient length to curl in the first place.
Dogs carrying the additional mutations for long coat (FGF5) and furnishings (RSPO2) will have furnishings and long soft coats, rather than wiry ones. When dogs carry variants in both FGF5 and KRT71, long and curly coat is seen.
If all three mutations (KRT71, FGF5 en RSPO2) are present, the phenotype is long and curly with furnishings.
References
Pubmed ID: 19713490
Year published: 2009
Omia ID: 245
Omia variant ID:
Turnaround information
- 10 working days