Primary hyperoxaluria II
Kodas: K601
Short description
Primary hyperoxaluria (PH) in cats is a genetic disorder caused by a recessive mutation in the GRHPR gene.
General information
Primary hyperoxaluria (PH) in cats is a genetic disorder caused by a recessive mutation in the GRHPR gene. The disorder is characterized by the overproduction of oxalate, which can lead to various urinary and kidney issues.
Specifications
| Breeds | All Breeds |
|---|---|
| Gene | GRHPR |
| Chromosome | D4 |
| Organ | Urinary system |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | PH2; Oxalosis II |
Clinical features
Oxalate accumulation can lead to urinary crystals or stones that can be painful and potential cause urinary system blockages and kidney damage and impaired function over time. Furthermore, affected kittens might show the following symptoms, depending on the location of the urinary stones: increased urination frequency, straining to urinate, blood in urine (hematuria), increased water intake and other symptoms of kidney failure and urinary tract blockage. When symptoms are severe, euthanasia on humane grounds can be performed. Symptoms appear usually between five and nine months of age.
References
Pubmed ID:
Year published: 2009
Omia ID: 821
Omia variant ID:
Turnaround information
- 10 working days