Sensory Neuropathy – All breeds
Kodas: H695
Short description
Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene.
General information
Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene. Animals with the disease show degeneration of sensory nerve cells and motor nerve cells.
This variant is for all breeds.
Specifications
| Breeds | All Breeds |
|---|---|
| Gene | FAM134B |
| Chromosome | 4 |
| Mutation | c.656C>T |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | SN |
Clinical features
Affected puppies manifest at approximately 7 months of age with ataxia (loss of coordination) in the limbs. The disease progresses to cause loss of sensation, "knuckling" of the hind paws and self-mutilation of the paws, which often necessitates surgical amputation of damaged toes.
References
Pubmed ID: 34387380
Year published: 2021
Omia ID: 2032
Omia variant ID:
Turnaround information
- 10 working days