Hereditary Footpad Hyperkeratosis (DSG1-related) – Rottweiler
Kodas: H777
Short description
Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths.
General information
Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths. This variant of the disorder, found in the Rottweiler, is caused by a recessive mutation to the gene DSG1. The disorder is also known as Palmoplantar Hyperkeratosis.
Specifications
| Breeds | |
|---|---|
| Gene | DSG1 |
| Chromosome | 7 |
| Mutation | c.2541_2545delGGGCT |
| Organ | Integumentary System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | HFH |
Clinical features
Symptoms for HFH affected dogs start at about 8 weeks of age, with footpads appearing unusually dry. The pads develop thick, rapidly-growing horny growths, which are painful and can cause additional discomfort while standing. The condition may also leave the dog more susceptible to additional skin and ear infections.
References
Pubmed ID: 32344723
Year published: 2020
Omia ID: 2266
Omia variant ID:
Turnaround information
- 10 working days