May-Hegglin Anomaly (MHA) – Pug
Kodas: H882
Short description
May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts.
General information
May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts. This variant of the disease, caused by a dominant mutation to the gene MYH9, has been observed in the Pug.
Specifications
| Breeds | |
|---|---|
| Gene | MYH9 |
| Chromosome | 10 |
| Mutation | c.5521G>A |
| Organ | Multiple systems |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant |
| Also known as | MHA |
Clinical features
Affected dogs display thrombocytopenia (lowered blood platelet counts), but might not necessarily develop any bleeding problems. Additionally, an affected dog may develop skin lesions and white plaques in the mouth following immunosuppressive treatment.
References
Pubmed ID: 21554370
Year published: 2011
Omia ID: 1608
Omia variant ID:
Turnaround information
- 10 working days