Exfoliative Cutaneous Lupus Erythematosus (ECLE)
Kodas: H980
Short description
Exfoliative Cutaneous Lupus Erythematosus (ECLE) is a severe immune disorder affecting the skin, causing skin lesions, crusts and hair loss.
General information
Exfoliative Cutaneous Lupus Erythematosus (ECLE) is a severe immune disorder affecting the skin, causing skin lesions, crusts and hair loss. The disease is caused by a recessive mutation to the gene UNC93B1, and is found in the German Shorthaired Pointer, Vizsla and related hunting dogs.
Specifications
| Breeds | Shorthaired Vizsla, Wirehaired Vizsla, German longhaired pointer, German Shorthaired Pointer |
|---|---|
| Gene | UNC93B1 |
| Chromosome | 18 |
| Mutation | c.1438C>A |
| Organ | Integumentary System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | ECLE |
Clinical features
Affected dogs present between the ages of 6 months and 3 years with the formation of skin scales, mainly on the face, ears and back. The skin may develop patchy, reddened lesions and clinging crusts, as well as general hair loss on affected areas. In later stages, some affected dogs may also experience severe joint pain.
References
Pubmed ID: 32028618
Year published: 2020
Omia ID: 1609
Omia variant ID:
Turnaround information
- 10 working days