Polydactyly (DC-2) – Dog
Kodas: H281
Short description
Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs.
General information
Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs. Specifically, polydactyly restores the first toe that was lost over the course of the evolution of the wolf, giving affected dogs a fifth toe known as a “dewclaw”. This specific variant (DC-2) is caused by a dominant mutation to the Limb Development Membrane Protein 1 (LMBR1) gene that affects the expression of the sonic hedgehog (SHH) gene.
This test measures the mutation known as DC-2. Another mutation, DC-1, is found in Sapsari and Tosa dogs.
Specifications
| Breeds | Biewer Terrier, Huntaway, New Zealand Heading Dog, Norwegian Lundehund, Poodle (Standard), Belgian Malinois, Schnauzer stándard, American Cocker Spaniel, Beagle, English Cocker Spaniel, Rottweiler, Shetland Sheepdog, Shih-Tzu, Yorkshire Terrier |
|---|---|
| Gene | LMBR1 |
| Chromosome | 16 |
| Organ | Skeletal system |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant |
Clinical features
Affected dogs develop an extra toe, or dewclaw, on their hind legs.
References
Pubmed ID: 18689889
Year published: 2008
Omia ID: 810
Omia variant ID:
Turnaround information
- 10 working days